TEACHING ACTIVITY COMMITTEE FOR Ph.D. SCHOOL
Prof. Elisa Greggio
Prof. Stefania Bortoluzzi
Prof. Matteo Griggio
Prof. Michela Zottini
ORGANIZATION OF THE TEACHING ACTIVITY
- Obligatory attendance of 10 seminars/year. Signature of speaker or college member is required.
- Obligatory attendance of 3 courses in 3 years.
- Obligatory attendance of 1 course/years paid by the Department of Excellence Project
- The seminars will be held ALWAYS on Thursday and Friday of the week, preferentially starting at 14.00.
- BIO-Ph.D. DAY in middle of June 2020 together with the Prize for Best photographs organized by Prof. Lanfranchi
8 scientific courses : 2 courses of 2 docents / CV
Approx. 4 h /course (tot. 32)
Ph.D. in Biosciences
Microscopy and imaging (Dr. Giacomello)
Ph.D. in Biosciences
Statistics in Biology (Proff. Romualdi/Eudukevicius)
Ph.D. in Biosciences
Scientific Publishing & Communication (TBD)
Ph.D. in Biosciences, Biomedical
Fellowship/grant proposal writing (Prof. Szabò, Prof. Scorrano)
Ph.D. in Biosciences
Gender balance (Ref. Prof. A. Rampazzo)
University of Padova
Models in Genetic Disease Research (Prof. Zordan)
Double diplom Padova-Paris
Visiting scientists (Cariparo)
Ph.D. in Biosciences
2 Visiting scientists (Department of Excellence)
Ph.D. in Biosciences Department of Biology
Mutuated courses from LM
Curriculum in Biochemistry and Biotechnology
- Molecular mechanisms of photosynthesis (from LM in Molecular Biology – T. Morosinotto)
Molecular mechanisms of photosynthesis (16h)
Speaker: Tomas Morosinotto
Mechanisms of the regulation of photosynthesis and strategies to improve plant yield and photosynthetic productivity.
Advanced in Biochemical Methods (8h)
Speaker: Luigi Leanza, Laura Cendron.
Date: September/October 2020.
The course will describe the more advanced and used biochemical methodologies:
- Principle of Mass Spectrometry and application to biological problems.
- New tools in the study of protein-protein interaction.
- Gene editing by CRISPR/Cas9 and its updated variants.
- High-throughput analysis.
Curriculum in Cell Biology and Physiology
Neurobiology and Neurophysiopathology: from molecules to organisms (6 hours).
Speakers: Laura Civiero, Lucia Manni, Marco Bisaglia, Elisa Greggio, Elena Ziviani, Luigi Bubacco.
Dates: 18-22 May 2020, 14.30 pm.
This course is organized in 6 lectures, each of them discussing novel aspects of neurophysiology and neurophatology.
1. Astrocytes in brain physiology. This lesson will discuss the past and recent discoveries on the glia field in health and disease with a specific focus on state-of-the art technologies and models.
2. Botryllus schlosseri as a model system to study neurogenesis and neurodegeneration. Morphological, behavioral and molecular features of adult individuals belonging to different cyclical phases and to colonies of different ages will be presented.
3. Dopaminergic pathways in physiology and pathology. Dopaminergic neurons are organized into four main pathways and play a central role in many mental and physical functions. This lecture will focus on the cell metabolism and mechanism of action of dopamine as a neurotransmitter as well as on the behavioral consequences induced by alterations in the metabolism of dopamine.
4. The gut-brain axis in neurodegenerative diseases. This lecture will first provide a general description of the physiology of the gut-brain axis, then it will discuss the recent evidence supporting the notion that Parkinson’s disease pathology may initiate in the gut and spread in the brain via the enteric nervous system.
5. Mitochondrial quality control in neurodegenerative diseases. After a short introduction on the molecular mechanisms that regulate macroautophagy and mitophagy, this lecture will explore the potential of enhancing basal mitophagy as therapeutic strategy to treat neurodegenerative diseases.
6. Physiopathology of alpha-synuclein at the dopaminergic synapse. In this lecture it will be discussed how reactive metabolites of the neurotransmitter dopamine may modify the Parkinson’s disease protein alpha-synuclein affecting its proteostasis, oligomerization and, in turn, synaptic function.
Cancer Biology and Therapies (4 hours)
Speakers: Massimo Santoro, Marina de Bernard, Elena Reddi and Francesca Moret.
Dates: 25-28 May 2020, 14.30 pm.
This course is organized in 4 lectures of 1 hour each. The aim of the lessons is to present some important features of the tumor tissues and cancer cell populations highlighting histological, physiological and molecular differences with respect to healthy cells and healthy tissues. Several differences between healthy and cancer cells/tissues pave the way for the development of therapeutic approaches.
1. Tumor angiogenesis. In this lesson it will be discussed the process and the molecular mechanisms of tumor angiogenesis.
2. Tumor immunity and immunotherapy of tumors. This lesson will be focused on the main mechanisms of tumor immune evasion and on the successful immunotherapies used to treat cancer.
3. Cancer stem cells. The following aspects will be discussed: cancer as a complex community formed by different types of cells; role of cancer stem cells in tumor growth and responses to therapies; properties of and markers for identifying cancer stem cells.
4. Cancer and nanomedicine. The main issues addressed in the lesson will be: the advantages offered by nanomedicine in cancer therapies; passive and active mechanisms for targeting tumors; nanocarriers for optimizing the delivery of anticancer drugs into tumors.
Curriculum in Evolution, Ecology and Conservation
Critical reading (10h)
Speaker: Clelia Gasparini
Date: October/November 2020.
This course will teach you how critically reading a scientific journal article. You will learn about effective strategies and habits to develop critical reading skills, and you will have the opportunities to practice these skills with your peers. You will learn why critical reading is important in scientific research and also how to review a paper for a journal. The course will consist of a mix of lectures and students’ presentations and discussions of published papers.
An Introduction to Methods and Models in Ecology, Evolution, and Conservation Biology (8h)
Speaker: Andrea Pilastro, 4 h lectures + 4 h discussions
Date: April/May 2020.
The course will provide an introduction to quantitative models and methods in ecology, behavioral ecology, evolutionary biology, and conservation. In particular, emphasis will be given to the design of experiments in relation to hypotheses and assumptions of interest. Students will be encouraged to present and discuss their future experiments, and discuss aims, predictions, statistical tests. The course will be based on study cases and examples from the literature.
- Sexual reproduction in flowering plants: cellular and molecular mechanisms (from LM in Molecular Biology) (16h).
Speaker: Prof Simon Hiscock
Dates: 5-8 November 2019, 8:30 am.
The aim of this series of 8 lectures is to familiarize students with fundamental cellular and molecular
aspects of sexual reproduction in angiosperms (flowering plants) framed within the context of their
evolutionary history among land plants, united by a shared aquatic green algal ancestor. The
relevance and importance of these fundamental processes to people and the planet will also be
Lecture 1: The unique reproductive biology of flowering plants.
Lecture 2: Male and female gametophyte development
Lecture 3: Molecular signalling during the pollen-pistil interaction I
Lecture 4: Molecular signalling during the pollen-pistil interaction II
Lecture 5: The genetic basis of self-incompatibility
Lecture 6: Molecular mechanisms of gametophytic self-incompatibility
Lecture 7: Molecular mechanisms of sporophytic self-incompatibility
Lecture 8: The importance of angiosperm sexual reproduction to people and the planet
Curriculum in Genetics, Genomics and Bioinformatics
Methods for Comparative Insect Chronobiology (Cinchron) (Prof. Costa/Sandrelli) (8h)
Speaker: various, the program of the conference will be uploaded on the website
Date: September 2020.
International course organized in occasion of the periodic meeting of the European project Marie Sklodowska-Curie ITN "Cinchron". Teaching ad practice activities will regard Computational methods for RNA-seq and transciptomic data analysis, Biostatistics, Comparative chronobiology, Adaptive role of circadian clocks, and Bioenergetics links with circadian clocks.
Essential and dispensable genes in living organisms (4h).
Speaker: Paola Venier
Date: June 2020.
The course will focus on genetic and evolutionary aspects of genome size and gene content, encompassing the following topics: 1) Genome size, architecture and evolutionary trends in viruses, prokaryotes and eukaryotes; 2) Microbial pan-genomes, how do they work? 3) Evidence for essential and dispensable genes in plants and animals. 4) The Mytilus dispensable gene fraction: practical implications for gene expression studies.
Advanced course of microscopy and imaging (8h).
Speaker: Marta Giacomello
1. Basic Principles of microscopy (2h)
Diffraction, Resolution and Contrast
Optics of the microscope
2. Fluorescence and Confocal Microscopy (2h)
Fluorescence microscopy (fluorophores, illumination…)
Basic Confocal microscopy (Lasers, multi-dimensional Image Recording …)
3. Fluorescent Probes (for fixed and live samples) (2h)
Chemical and genetically encoded
Ratiometric - Non ratiometric
4. Advanced techniques in fluorescence microscopy (2h)
(FRET, TIRF, FRAP) and Super resolution microscopy
High content Imaging
Statistics in Biology (Proff. Romualdi/Eidukevicius) (April/May 2020) (16h).
Course: Statistical analysis for Biological Data: the univariate case
- Introduction to plots, descriptive statistics and Statistical Inference
- T-test for paired and unpaired data, one-way ANOVA
- Multi-way ANOVA, ANCOVA, Non-parametric tests
- Statistical power, how to determine the right sample size for your experiment
- Conclusion: the right way of reporting statistical results on scientific journals
Course: Biological data analysis with R and R notebook
- R language fundamentals and basic syntax
- R data structures
- Visualizations and inference using R
- Writing reports with R notebook
Course: Multivariate Statistical Analyses
- Introduction to multivariate regression analyses
- Dimension reduction techniques (Clustering and Principal Component Analyses)
- Logistic regression Analyses
- Survival Models
- Concluding Remarks
Fellowship/grant proposal writing (Prof. Szabò, Prof. Scorrano) (June/July 2020) (8h).
The course offers the theoretical framework and practical advice on how to successfully write a post-doctoral fellowship application for a competitive international grant program (such as EMBO, Marie-Curie, Human Frontiers, and so on). The course will concentrate on:
- Who will pay my postdoc: Choice of the agency where to apply
- Structure of a post-doctoral fellowship application: how to navigate the different requirements of the different agencies
- The core of the proposal: grantmanship of a well-organized, scientifically sound project.
- The application clinics: write your mock, trial application and get it corrected by the experts.
TEACHING ACTIVITY OFFERED BY THE DEPARTMENT OF EXCELLENCE PROGRAM
2 courses for spring 2020
3 courses for spring 2021
3 courses for 2022
For SPRING 2020:
- "Sexual conflicts" by Tamas Szekely (University of Bath, UK) (evolution, population genetics, genetics) (June 8-9).
- Cannabis and nicotine - plant secondary metabolites and how they function in plants and humans by Ute Vothknecht (University of Bonn, Germany) (cell biology, physiology, plant biology, biochemistry) (May..).